Retinol to Retinol-Binding Protein (RBP) Is Low in Obese Adults due to Elevated apo-RBP
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چکیده
منابع مشابه
Retinol-binding protein (RBP) and pigmentary dystrophy of the retina.
Vitamin A (retinol) is a fat-soluble alcohol and is derived in the upper part of the small intestine from carotenoid plant pigments and Vitamin A esters present in food (Olson, I964). The free retinol then penetrates through the mucosal cells, perhaps aided by its polar or hydrophilic hydroxy group, and is re-esterified during transit (Glover and Walker, I 964). After absorption it reaches the ...
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Vitamin A-transporting protein in chicken plasma was purified by column chromatography on DEAE-Sephadex and Sephadex G-100; the protein formed a complex of retinol-binding protein (RBP) with prealbumin (PA). The molecular weight of the 1:1 molar complex was estimated to be 76,000 by gel filtration, and the sedimentation coefficient (S20,W) was found to be 5.2 S. RBP and PA were dissociated from...
متن کاملMuscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice.
Mice lacking retinol-binding protein (RBP) have low circulating retinol levels. They have severe visual defects due to a low content of retinol or retinyl esters in the eye. A transgenic mouse strain that expresses human RBP under the control of the muscle creatine kinase promoter in the null background was generated. The exogenous protein bound retinol and transthyretin in the circulation and ...
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We recently demonstrated a rapid up-regulation of serum retinol-retinol binding protein-transthyretin concentration in rats with short-term acute renal failure. We examine the effect of retinoic acid and apo-retinol binding protein (apo-RBP) on the up-regulation of serum retinol in renal failure. Injection of retinoic acid (10 micrograms) into rats with acute renal failure or sham-operated rats...
متن کاملAlbumin, transferrin and the thyroxine-binding prealbumin/retinol-binding protein (TBPA-RBP) complex in assessment of malnutrition.
A comparative study of the level of 4 plasma proteins in malnutrition shows that albumin has low sensitivity, transferrin has intermediate and the TBPA-RBP complex has the highes sensitivity to an alteration in the nutritional status. According to protein and/or iron deficiency, the synthesis of trnasferrin seems to be submitted to contradictory impulses which partially invalidates this test as...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2008
ISSN: 1535-3702,1535-3699
DOI: 10.3181/0803-rm-94